Unlike most oral steroids, which
are Class II steroids giving most of their anabolic effect by
means other than the androgen receptor (AR), it seems that
oxandrolone probably does have good binding to the AR, and is
therefore a Class I steroid, while having little other effect.
By itself it is considered to be a weak anabolic.
Partly this is due to its apparent lack of non-AR-mediated
activity. This can be corrected of course by stacking with a
Class II steroid such as dianabol,
anadrol, 4-AD, or
nor-4-AD: the latter two steroids require high blood levels
which are not obtained by oral use of the powders.
The other part of the reason for this is that bodybuilders
make unfortunate and unreasonable comparisons when judging
anabolic steroids. If say 8 tablets per day does little, then
the drug is pronounced useless or weak by the user. But that is
only 20 mg/day, or 140 mg/week. Does 140 mg/week testosterone
give much results? No. Few anabolic steroids give dramatic
results at that dose. Per milligram the potency is reasonable,
but each individual tablet is weak because the dosage is small.
Because of its high price, very few bodybuilders have taken
large doses of oxandrolone.
There is a single case in the medical literature (Forbes et al.)
where it is reported that a competitive athlete
self-administered 150 mg oxandrolone per day with remarkable
gains. This is of uncertain credibility because unless
urinalysis was done to verify that no other steroids were taken,
there is no way to be certain that the athlete did not actually
take more drugs than he reported. In any case, at current
prices, only the quite wealthy could afford such a dose. I
personally have tried 150 mg/day and considered it somewhat
effective, but not dramatically so, and not a preferred regimen.
Oxandrolone does not aromatize or convert to DHT, and has a
longer half life than Dianabol - 8 hours vs. 4 hours. Thus, a
moderate dose taken in the morning is largely out of the system
by night, yet supplies reasonable levels of androgen during the
day and early evening.
Oxandrolone shares the liver toxicity problems common to
17-alkylated steroids. At one time it was thought that it did
not, but both clinical and practical experience with Oxandrin
has shown that at doses of 40 mg/day and higher, liver
toxicity is indeed an issue with prolonged use.
Primobolan, I believe, should
be considered a superior compound, offering the same activity at
(usually) a lower price and without the alkylated-toxicity
issue.
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