Methandrostenolone converts to estradiol via aromatase. The amount of this conversion may be reduced by use of Arimidex, or less preferably Cytadren (see previous articles discussing dosage and dose pattern.) Or if the conversion is allowed, Clomid may be used to block adverse estrogenic effects.

Irreversible hoarsening of the voice has been seen in some women from very few tablets of Dianabol: one per day for a few weeks. For this reason, in the 1960s doctors decided to end what had been a fairly common practice of prescribing this drug at one tab per day to women as a "tonic." It is not a good choice for the woman who chooses to use anabolic steroids.

The usual dosing for men is 25-50 mg/day in divided doses, preferably four or five doses. The drug is 17-alkylated and so use should be limited to no more than 6 weeks, and preferably no more than four weeks, with at least an equal amount of time off.